Morphological Audit of glomerular diseases in a tertiary care Hospital.




Focal Segmental Glomerulosclerosis, Membranous Glomerulonephritis, Mesangiocapillary Glomerulonephritis, Pre-Spike Membranous Glomerulonephritis, Immunofluorescence, Silver Stain.


Background: Glomerular diseases are a universal health issue, and Pakistan ranks eighth in renal disease, causing 20,000 deaths every year. Renal biopsy is a valuable diagnostic tool and provides prognostic insight and therapeutic plans. The study's objective is to determine the frequency and pattern of various glomerulopathies concerning age and gender.

Methodology: A cross-sectional study was performed at the Department of Pathology, Ziauddin Medical University, and Hospital, Karachi, from 19th December 2018 to 15th April 2019. A total of 91 patients were included of either gender with a clinical history of glomerulonephritis. All biopsy samples were analyzed by using light and immunofluorescence microscopy techniques. Patient data were compiled and analyzed through SPSS version 20.0.

Results: A total of 91 cases of the renal biopsy were evaluated; 51.6% of these cases were male patients. Forty-nine (53.8%) cases were reported as focal segmental glomerulosclerosis, 35(38.5%) were diagnosed with membranous glomerulonephritis, and 7(7.7%) were reported as mesangiocapillary glomerulonephritis. In membranous glomerulonephritis, 7.7% were pre-spike membranous glomerulonephritis. In the current study, 35.2% of cases showed diffuse glomerular basement membrane (GBM) thickening with spikes, and 4.4% showed GBM thickening with focal spikes on silver stain.

Conclusion: Glomerular diseases are slightly more prevalent in males than females. The most commonly diagnosed primary glomerulonephritis was focal segmental glomerulosclerosis, followed by membranous glomerulonephritis.




How to Cite

Shafique, M., Bukhari, U., Kumar, S., George, A., Bukhari, A., & Sajjad, M. (2022). Morphological Audit of glomerular diseases in a tertiary care Hospital. International Journal of Endorsing Health Science Research, 10(1), 95–101.