Oxidative stress level among females with Type 2 Diabetes Mellitus with & without Polycystic Ovarian Syndrome.

Abstract

Background: The present study aimed to evaluate the level of oxidative stress by measuring the plasma concentration of oxidants in Type 2 Diabetes Mellitus (T2DM) patients with and without Polycystic Ovarian Syndrome (PCOs).

Methodology: A total of 500 diabetic patients between 25 to 45 years of age were divided into two groups; group 1 included 250 T2DM patients with PCOs, and 250 T2DM patients without PCOs were included in group 2. In addition to the demographic and clinical parameters, antioxidants include Superoxide Dismutase (SOD), Malondialdehyde (MDA), Catalase (CAT), Total antioxidant capacity analyte (TAC), and Glutathione Peroxidase (GSH) was also measured.   

Results: No significant difference in the level of antioxidants; SOD and MDA was observed between the diabetic females with and without PCOs (p>0.05). However, Glutathione Peroxidase (GSH-Px) was significantly low in T2DM patients with PCOs as compared to those without PCOs (p<0.05). Surprisingly, the mean catalase levels were significantly high among T2DM females with PCOs (3.6 ± 0 .5 U/g of Hb) than those without PCOs (3.4 ± 0.7 U/g of Hb; p<0.001).

Conclusion: It is suggested that both T2DM and PCOs are linked to a high level of oxidative stress status, but the high catalase level among diabetic PCOs females is alarming and needs to be further studied. Thus, these changes accentuate the need for lifestyle modifications.