Bone Mineral Density among adolescent's patients with β-thalassemia major.


  • Samar Abbas Jaffri Department of Medicine, Liaquat National Hospital & Medical College, Karachi-Pakistan.
  • Syed Muhammad Irfan Department of Hematology & Blood bank, Liaquat National Hospital & Medical College, Karachi-Pakistan
  • Sadia Sultana Laboratory, National Medical Centre, Karachi-Pakistan
  • Syed Muhammad Usman Jinnah Medical & Dental College, Karachi-Pakistan
  • Sheeza Nadeem Jinnah Medical & Dental College, Karachi-Pakistan



Beta-Thalassemia Major, Bone Mineral Density, Osteoporosis, Osteopenia, Dual-Energy X-Ray Absorptiometry.


Background: Beta-thalassemia is an autosomal recessive hemoglobinopathy with frequent skeletal complications, often debilitating in adolescent patients. We aim to evaluate the bone mineral density (BMD) by dual-energy x-ray absorptiometry (DEXA) and ascertain osteoporosis/osteopenia frequency in patients with β-thalassemia major.

Methodology:  In this cross-sectional study, 36 adolescent patients with β-thalassemia major were enrolled from June 2015 to March 2017.  BMD was measured in the anteroposterior lumbar spine (L1-L4) and femoral neck by DEXA. For the biochemical estimations, blood and urine samples were obtained and analyzed. The results of a bone density test were presented as T and Z scores.

Results: There were 20 male and 16 female patients with a mean age of 21.33 ± 3.7 years. The mean bone mineral content (BMC) was 20.10 ± 6.0 gm, and the mean BMD was 0.65 ± 0.07 gm/cm2. The mean T score was -3.17 ± 1.04, and the Z score was -3.06 ± 1.06. All patients had low BMD, as depicted by their T or Z scores. The reported frequency of osteoporosis and osteopenia was 77.7% and 22.2%, respectively.

Conclusion: All Beta-thalassemia major patients had low BMD with a remarkable incidence of osteoporosis. It is recommended to perform an annual BMD among thalassemic patients to prevent fatal consequences and achieve an optimal bone density among such patients.




How to Cite

Abbas Jaffri, S., Syed Muhammad Irfan, Sultana, S., Syed Muhammad Usman, & Nadeem, S. (2021). Bone Mineral Density among adolescent’s patients with β-thalassemia major. International Journal of Endorsing Health Science Research, 9(1), 42–47.