Assessing BDNF correlations with non-invasive indicators of neurological decline in different age groups

Syeda Faiza Batool; Faizan Mirza

doi:10.29052/2412-3188.v9.i2.2022.106-115

Syeda Faiza Batool Psychophysiology Research Lab, M.A.H.Q Biological Research Centre, UoK
Faizan Mirza 1Psychophysiology Research Lab, M.A.H.Q Biological Research Centre, UoK 2Department of Physiology, University of Karachi, Karachi-Pakistan.

DOI: https://doi.org/10.29052/2412-3188.v9.i2.2022.106-115

Keywords: Aging, Brain Derive Neurotrophic Factor, Verbal Fluency Test, Cognitive Impairment/Cognitive Decline

Abstract

Background: Health is the prime concern of the modern world, and with the increasing life span, both the physical and mental health of human being decline, eventually affecting the cognitive abilities of a person, which may be due to normal aging processes or neuropathological reasons. A cross-sectional study investigated the relationship between BDNF level, neurological disturbance, and aging.

Methodology: Cognitive assessment is done through verbal fluency test (FAS, DSST, and 6CIT) and BDNF level in blood found through HPLC utilizing the ALIZA kit method.

Results: Descriptive statistics were applied for continuous variables. Hence, one-way ANOVA was performed to show the relationship between cognitive parameters and aging.

Conclusion: Our study reports that verbal fluency disturbs as lifetime increases, although sex, education, obesity, or lifestyle does not affect cognition.

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