Correlation of copeptin with osmolarity  and electrolytes in diabetes Mellitus: A tertiary center outpatient experience.

Tooba Noor; Zareen Kiran; Arif Ali; Sadiqa Badar Syed; Farina Hanif

doi:10.29052/IJEHSR.v10.i2.2022.157-166

Tooba Noor Department of Physiology, Dow University of Health Sciences, OJHA Campus, SUPARCO Road, Karachi-Pakistan. http://orcid.org/0000-0003-3709-201X
Zareen Kiran National Institute of Diabetes and Endocrinology, Dow University of Health Sciences, OJHA Campus, SUPARCO Road, Karachi-Pakistan. http://orcid.org/0000-0003-3422-9359
Arif Ali School of Public Health, Dow University of Health Sciences, OJHA Campus, SUPARCO Road, Karachi-Pakistan. http://orcid.org/0000-0002-1497-8144
Sadiqa Badar Syed Department of Physiology, Dow University of Health Sciences, OJHA Campus, SUPARCO Road, Karachi-Pakistan. http://orcid.org/0000-0003-4518-4598
Farina Hanif Department of Biochemistry, Dow University of Health Sciences, OJHA Campus, SUPARCO Road, Karachi-Pakistan. http://orcid.org/0000-0002-7458-8367

DOI: https://doi.org/10.29052/IJEHSR.v10.i2.2022.157-166

Keywords: Arginine Vasopressin, Copeptin, Electrolytes, Osmolarity, Diabetes Mellitus.

Abstract

Background: Arginine Vasopressin (AVP) plays a significant role in the pathophysiology of Diabetes Mellitus (DM) and its related nephropathy. Timely detection of copeptin, a surrogate biomarker of AVP, would help in minimizing the osmoregulatory complications secondary to DM. The study aimed to correlate serum copeptin levels with serum osmolarity and electrolytes in subjects with progressive stages of DM.

Methodology: A total of 120 patients were recruited as controls, pre-diabetes, DM without nephropathy, and nephropathy. Serum copeptin levels were measured by Enzyme-Linked Immunosorbent Assay. At the same time, routine biochemical tests for diabetes and renal function were done from the affiliated diagnostic laboratory.

Results: The mean copeptin and osmolarity levels were 207.74 ± 192.08 pg/ml and 302.29 ± 18.13 mOsm/kg, respectively. Both, the copeptin and osmolarity levels raises progressively from controls to various stages of DM and share significant positive correlation (r=0.214, p=0.019). Osmolarity was also correlated significantly with RBS (r=0.262), BUN (r=0.844), Na+ (r=0.210) and K+ (r=0.461).

Conclusion: The significant correlation of copeptin with osmolarity highlights the importance of the AVP system in regulating body fluid equilibrium in diabetic patients progressing towards nephropathy. Timely detection of copeptin can play an important role in the early management of the disease.

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