Preliminary study of variation in pre and post hematological values of healthy plateletpheresis donors.

Keywords: Plateletpheresis, Platelet Count, Thrombocytopenia, Blood Donor, Cancer.


Background: At this instant, automated cell separators are used for the purification of platelets from healthy donors but the donor’s safety should not be overlooked. Hence, the present study aimed to compare the effect of platelet apheresis (via mega unit) on hematological indices of healthy donors.

Methodology: In this cross-sectional study, 100 samples of healthy plateletpheresis or thrombopheresis donors were included. The pre and post plateletphresis hematological parameters were assessed. The total platelet count (PLT), hemoglobin (Hb), white blood cells count (WBCs), red blood cells count (RBCs), mean cell volume (MCV), mean cell hemoglobin (MCH) or mean corpuscular hemoglobin concentration (MHCH) were estimated through complete blood count (CBC) analysis and platelet apheresis was done by Mega unit Haemonetics MCS+9000 Cell Separator and 994- CFE.

Results: After platelet apheresis procedure, a significant decrement in PLT value (p-value <0.001). And with that a remarkable difference was also observed in the haemoglobin, MCH and MCHC. 

Conclusion: In conclusion, the hematological parameters significant decree among donors after the procedure of platelet aphresis but the revealed characteristics of thrombocytopenia and anemia were not found.


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1. Elaskalani O, Berndt MC, Falasca M, Metharom P. Targeting Platelets for the Treatment of Cancer. Cancers. 2017;9(7):1-23.
2. Afdhal N, McHutchison J, Brown R, Jacobson I, Manns M, Poordad F, Weksler B, Esteban R. Thrombocytopenia associated with chronic liver disease. J Hepatol. 2008;48(6):1000-1007.
3. Ojha A, Nandi D, Batra H, Singhal R, Annarapu Gk, Bhattacharyya S, Seth T, Dar L, Medigeshi GR, Vrati S, Vikram NK, Guchhait P. Platelet activation determines the severity of thrombocytopenia in dengue infection. Sci Rep. 2017;7(1):1-10.
4. Amar RS, Chaudhari SN, Shah MH. Role of platelet parameters in diagnosing various clinical conditions. Nati J Med Res. 2013; 3(2): 162-165.
5. Azeredo ELD, Robson Q, Monteiro, Pinto LM. Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators. Mediat Inflamm. 2015;8:1-16.
How to Cite
Aslam, M. U., Alam, M., Zafar, M. U., Akhter, M., Awais, H., Mannan, T., & Javaid, S. (2021). Preliminary study of variation in pre and post hematological values of healthy plateletpheresis donors. International Journal of Endorsing Health Science Research (IJEHSR), 9(3), 360-364.