International Journal of Endorsing Health Science Research (IJEHSR) <p><strong>International journal of endorsing health science research (IJEHSR)</strong>&nbsp;aims to&nbsp;improve health care by providing the most recent research results&nbsp;leading to advancement in health science.</p> <p><strong>IJEHSR</strong>&nbsp;is quarterly, open access, peer-reviewed&nbsp;journal keen to endorse the need for finest healthcare globally, it was founded in 2013 as a biannual journal, and converted into quarterly in 2015. &nbsp;<strong>IJEHSR</strong>&nbsp;is included in the journal list of International Committee of Medical Journal Editors (ICMJE) since 2014. This Journal is indexed by WHO Index Medicus (IMEMR) for the Eastern Mediterranean Region.&nbsp;<strong>IJEHSR</strong>&nbsp;editorial board members are working in diverse fields of health care in countries like&nbsp;<strong>Pakistan, Canada, Australia, United States of America, China, India, Oman,&nbsp;Saudi&nbsp;Arabia,&nbsp;</strong>and<strong>&nbsp;Ethiopia.</strong></p> <p>We would like to encourage you to submit your intellectual effort in&nbsp;IJEHSR, we consider manuscripts from all fields of health sciences.&nbsp;The journal publishes original research, reviews, clinical reports, case studies, legal and policy perspectives.</p> Advance Educational Institute and Research Center en-US International Journal of Endorsing Health Science Research (IJEHSR) 2307-3748 <p>By submitting a manuscript in&nbsp;<strong>IJEHSR</strong>, the Author (Authors if a multi-authored paper) confirms all the clause of the <a href="">Copyright Notice</a></p> Dose dependent effect of ginseng on high fat diet induced hyperlipidemia in rats: A preventive clue for coronary artery diseases in experimental rats. <p><strong>Background:</strong> Coronary artery diseases are among the most challenging diseases in this era. Improper dietary habits and sedentary lifestyles are considered as foundation stones for metabolic disorders, including hyperlipidemia, the leading cause of coronary artery diseases and hypertension. This experiment was designed to study the dose-dependent effect of ginseng on high fat diet induced hyperlipidemia in animal models.<br><strong>Methodology:</strong> This experimental study was conducted at Dow University of Health Sciences, including 50 male Albino Wistar rats. The rats were randomly divided into 5 groups of 10 animals each. Group 1 was on a normal balanced diet; group 2 was on a high fat diet (HFD), group 3 was on HFD plus ginsenoside 100 mg/kg body wt, group 4 was on HFD plus ginsenoside 200 mg/kg body wt, group 5 was on HFD plus ginsenoside 400 mg/kg body wt. Animals were sacrificed after 12 weeks; blood was drawn then sent to DDRRL for lipid profile. <br><strong>Results:</strong> The results revealed that HFD increases body fats, weight increases from initial weight to 27.53% in obese control group 2 while after treating with ginsenoside weight reduced to 11.6%. Lipids levels in the blood; in the obese control group, mean triglyceride level increases from 45 mg/dl to 128.50 mg/dl, mean cholesterol level from 56.3 mg/dl to 106.2 mg/dl and low-density lipoprotein (LDL) is increased from 6 to 11.9 mg/dl. While concurrent administration of ginseng root extract (ginsenoside) reduces the Lipid levels in blood according to the dosage of ginseng root extract, the mean triglyceride level in group 4 is reduced to 46.10 mg/dl from 128.50 mg/dl. The mean cholesterol level in group 4 is reduced to 400 mg/dl from 106.2 mg/dl. LDL is reduced in group 4 to 7.5 mg/dl from 11.9 mg/dl. <br><strong>Conclusion:</strong> This study provides evidence that Ginsenoside has an anti-hyperlipidemic effect, so it might be helpful in preventing coronary artery disease.</p> Rabia Rehan Sahar Mubeen Fauzia Imtiaz Mahrukh Kamran Mohammad Sarfaraz ##submission.copyrightStatement## 2021-09-25 2021-09-25 Comparison of SAPS III and SOFA score for the prediction of mortality among ICU patients. <p><strong>Background:</strong> The present study was designed to assess the comparative performance of the Simplified Acute Physiology Score III (SAPS III) and sequential organ failure assessment (SOFA) score in predicting mortality among critically ill ICU patients.</p> <p><strong>Methodology:</strong> A cross-sectional study was conducted from January 2019 to December 2019, including 162 patients admitted to the medical intensive care unit (ICU) of PIMS, Islamabad. The SOFA and SAPS III scores were calculated for all patients on admission. Outcome parameters included death or discharge from the hospital and disability. The receiver operating characteristic (ROC) curve was constructed for the studied models, and the scores were correlated with mortality.</p> <p><strong>Results:</strong> The overall mortality rate in the studied population was 46.9%. The mean SAPS III and SOFA scores were 55.26±18.46 and 14.41±5.67, respectively. The area under the ROC curve (aROC) for the SAPS III was 0.71 at a cut-off value of 43.5, whereas the aROC for SOFA was 0.64 at a cut-off score of 12.5. The ROC curve for predicting hospital mortality exhibited that both SAPS III and SOFA scores were sensitive predictors of mortality, given SAPS III had relatively better prediction (85%) compared to SOFA (76%).</p> <p><strong>Conclusion:</strong> It is concluded that SAPS III and SOFA scores are sensitive predictors of mortality; however, SAPs score is better at predicting mortality than SOFA score.</p> <p>&nbsp;</p> Ahmed Farhan Syed Muneeb Ali Valeed Bin Mansoor Rabail Chaudhary Hassan Ur Rehman ##submission.copyrightStatement## 2021-09-25 2021-09-25