TY - JOUR AU - Abbas Jaffri, Samar AU - Syed Muhammad Irfan, AU - Sultana, Sadia AU - Syed Muhammad Usman, AU - Nadeem, Sheeza PY - 2021/03/01 Y2 - 2024/03/29 TI - Bone Mineral Density among adolescent's patients with β-thalassemia major. JF - International Journal of Endorsing Health Science Research JA - Int. j. endorsing health sci. res. VL - 9 IS - 1 SE - Original Article DO - 10.29052/IJEHSR.v9.i1.2021.42-47 UR - https://aeirc-edu.com/ojs14/index.php/ijehsr/article/view/294 SP - 42-47 AB - <p><strong>Background:</strong>&nbsp;Beta-thalassemia is an autosomal recessive hemoglobinopathy with frequent skeletal complications, often debilitating in adolescent patients. We aim to evaluate the bone mineral density (BMD) by dual-energy x-ray absorptiometry (DEXA) and ascertain osteoporosis/osteopenia frequency in patients with β-thalassemia major.</p><p><strong>Methodology:</strong>&nbsp;&nbsp;In this cross-sectional study, 36 adolescent patients with β-thalassemia major were enrolled from June 2015 to March 2017.&nbsp; BMD was measured in the anteroposterior lumbar spine (L1-L4) and femoral neck by DEXA. For the biochemical estimations, blood and urine samples were obtained and analyzed. The results of a bone density test were presented as T and Z scores.</p><p><strong>Results:</strong>&nbsp;There were 20 male and 16 female patients with a mean age of 21.33 ± 3.7 years. The mean bone mineral content (BMC) was 20.10 ± 6.0 gm, and the mean BMD was 0.65 ± 0.07 gm/cm<sup>2</sup>. The mean T score was -3.17 ± 1.04, and the Z score was -3.06 ± 1.06. All patients had low BMD, as depicted by their T or Z scores. The reported frequency of osteoporosis and osteopenia was 77.7% and 22.2%, respectively.</p><p><strong>Conclusion:</strong>&nbsp;All Beta-thalassemia major patients had low BMD with a remarkable incidence of osteoporosis. It is recommended to perform an annual BMD among thalassemic patients to prevent fatal consequences and achieve an optimal bone density among such patients.</p> ER -