Combined accuracy of Procalcitonin and Quick Sequential Organ Failure Assessment (qSOFA) in predicting 3-days in-hospital mortality in suspected sepsis.

Keywords: Sepsis, Mortality, Procalcitonin, Organ Failure.

Abstract

Background: Early identification of sepsis is important for initiating appropriate treatment for decreasing the risk of in-hospital mortality. To determine the diagnostic accuracy of procalcitonin (PCT) and quick sequential organ failure assessment (qSOFA) in predicting 3-days in-hospital mortality in suspected sepsis.

Methodology: A cohort study was conducted at the emergency department of Ziauddin University Hospital, Karachi. One-hundred and thirty-two suspected cases of sepsis having age 18-75 years were selected through convenience sampling. PCT level and qSOFA score were obtained for predicting 3-days in-hospital mortality.

Results: Of the study patient, 50.8% were male, and 49.2% were female, with a mean age of 53.7 ± 18.3 years. The mean qSOFA score was 1.8 ± 0.5, and the mean PCT level was 2.7 ± 12.5 ng/ml. The combined QSOFA and PCT 3-days in-hospital mortality prediction was 31.1%, while the actual mortality rate was 28.0%. The combined qSOFA score and PCT level sensitivity was 62.2%, specificity 81.1%, positive predicted value 56.1%, negative predicted value 84.7%, and diagnostic accuracy 75.8%.

Conclusion: The combined use of QSOFA and PCT improves the 3-day in-hospital mortality prediction in suspected cases of sepsis.

Downloads

Download data is not yet available.

References

1. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801-810.
2. Finfer S, Machado FR. The global epidemiology of sepsis. Does it matter that we know so little?. Am J Respir Crit Care Med. 2016;193(3):228-230.
3. Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T, Schlattmann P, Angus DC, Reinhart K.. Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations. Am J Respir Crit Care Med. 2016;193(3):259-272.
4. Sepsis Alliance Pakistan. Karachi sepsis declaration: commitment to improve sepsis awareness, early recognition, prevention, care, and research in Pakistan. Global Sepsis Alliance; 2019.
5. Wang HE, Jones AR, Donnelly JP. Revised national estimates of emergency department visits for sepsis in the United States. Crit Care Med. 2017;45(9):1443-1449.
Published
2021-12-22
How to Cite
Memon, T. A., Butt, S., Khalid, I., Dehrab, N., Afsheen, N., Jamil, M., & Ulhaq, E. (2021). Combined accuracy of Procalcitonin and Quick Sequential Organ Failure Assessment (qSOFA) in predicting 3-days in-hospital mortality in suspected sepsis. International Journal of Endorsing Health Science Research (IJEHSR), 9(4). Retrieved from http://aeirc-edu.com/ojs14/index.php/IJEHSR/article/view/764