The study of immunity dysfunction and high susceptibility of infections in patients with diabetes and pre-diabetes: A prescription based study
Background: Diabetes, being the most prevalent co-morbidity associated with various metabolic complaints and is considered as the principal emerging health issue of 21st century. As along with conformist complications, the disease due to having immuno-deficiency characteristics that leads to low functioning of T-cells and neutrophils consequently becomes highly accountable for frequent infections. The present study was conducted to analyze the co-morbidity of infections with diabetes and to describe and control the foremost complications of infectious diseases and their management allied with this metabolic disorder.
Methodology: A cross sectional prospective study was conducted in the diabetic clinics of public and private sector hospitals of Karachi. 170 diabetic patients were included in the study, 26 were tested to be pre-diabetic and while the remaining 144 were not only diabetic also on antibiotics. The data was analyzed using the SPSS version 17.
Results: The data of study reveals that the frequency of infection was found utmost in diabetic patients, as the antibiotics prescription rate and antiseptic utilization for treating various infections was increased among these cases. As among 144 diabetic patients 50% were found to have frequent infection as were often prescribe antibiotics.
Conclusion: We concluded, severe hyperglycemia can drastically alter body immune response against pathogens, that strongly favors the deprived outcomes and severe complications. Health care professionals are required to encourage the patients to follow the recommendations and guidelines to reduce the morbidity of diabetes along with infection and prescribe drugs of choice for the management of pathogenic bacteria at early phase to avoid the severity of pathogenicity and recommendation of supplements and medicine that enhances the immunity must be enforced.
2. Murtha MJ, Eichler T, Bender K, Metheny J, Li B, Schwaderer AL, Mosquera C, James C, Schwartz L, Becknell B, Spencer JD. Insulin receptor signaling regulates renal collecting duct and intercalated cell antibacterial defenses. J Clin Invest. 2018;128(12):5634-5646.
3. Jafar N, Edriss H, Nugent K. The effect of short-term hyperglycemia on the innate immune system. Am J Med Sci. 2016;351(2):201-211.
4. Lachmann G, Wollersheim T, Spies C. Severe perioperative hyperglycemia attenuates postoperative monocytic function, basophil count and T cell activation. Minerva Anestesiol. 2017, 83(9):921-929.
5. Abu-Ashour W, Twells LK, Valcour JE, Gamble JM. Diabetes and the occurrence of infection in primary care: a matched cohort study. BMC Infect. Dis. 2018; 18(1): Article 67.
By submitting a manuscript in IJEHSR, the Author (Authors if a multi-authored paper) confirms all the clause of the Copyright Notice