Identifying relationship of lipid profile with hypertension among diabetic patients

  • Muhammad Ahmad Alamgir Department of Medicine, Civil Hospital, Bahawalpur
  • Irum Alamgir Quaid-e-Azam Medical College, Bahawalpur
  • Shafique Aqil Department of medicine, Quaid-e-Azam Medical College, Bahawalpur
  • Masroor Ali Qazi Department of medicine, Quaid-e-Azam Medical College, Bahawalpur
  • Ali Imran Department of medicine, Quaid-e-Azam Medical College, Bahawalpur
  • Javeria Aslam Department of Medicine, Civil Hospital, Bahawalpur
  • Humanyun Hassan Department of Medicine, Civil Hospital, Bahawalpur
Keywords: Diabetes Mellitus, Hypertension, High-Density Lipoprotein Cholesterol, Total Cholesterol, Triglycerides

Abstract

Background: Relevant literature suggests that hypertension (HTN) is commonly linked with lipid abnormalities among diabetics so management of dyslipidaemia may reduce the cardiovascular complications significantly. The study was aimed to evaluate whether dyslipidaemia was associated with HTN among type 2 diabetics.

Methodology: This hospital-based, observational, retrospective and comparative study was carried out from January 2018 to June 2018 in the medical outdoor department of Bahawal Victoria Hospital (BVH), Bahawalpur. The study sample was comprised of 50 normotensive diabetic patients as control (group A) and 50 diabetic subjects with HTN were labeled as group B. Comparative values of lipids were primarily observed between the two groups. Quantitative demographic data, blood pressure (BP) recordings, laboratory values of lipid and serum sugar levels were presented as percentage, mean and standard deviation accordingly. To determine statistical assessment, Statistical Package for the Social Sciences (SPSS) version 15 was used and Student t-test was applied to compare the means of two groups for lipoproteins with significance level at 5%.

Results: Analytic results of this study showed that hypertensive subjects (group B) had hyperlipidemia along with uncontrolled hyperglycemia as well. Among them, high-density lipoprotein cholesterol (HDL- C) was 32.73±4.47mg/dl while in normotensive control (group A) it was 39±2.94 mg/dl. Same with the total cholesterol (TC) and triglycerides (TG), both lipoproteins were observed in greater concentrations among hypertensive patients as 194.68±31.75mg/dl and 196.05±78.45mg/dl respectively, compared to control (179.07±38.61mg/dl and165.75±48.80mg/dl respectively). Hyperlipidaemia was defined according to guidelines for diabetic patients provided by the National Cholesterol Education Program /American Diabetes Association (NCEP/ADA).

Conclusion: It can be concluded from the study results that diabetics having HTN have more susceptibility towards hyperlipidemia when compared to the normotensive diabetic.

References

American Diabetes Association. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes—2018. Diabetes Care. 2018; 41(Supplement 1):S86-104.

Benjamin EJ, Virani SS, Callaway CW, Chang AR, Cheng S, Chiuve SE, Cushman M Statistics Committee and Stroke Statistics 2018 update: a report from the American Heart Association [Heart disease and stroke statistics online ahead of print January 31, 2018]. Circulation. 2018;137(12):e67-e492.

Basit A, Fawwad A, Qureshi H, Shera AS. Prevalence of diabetes, pre-diabetes and associated risk factors: second National Diabetes Survey of Pakistan (NDSP), 2016–2017. BMJ open. 2018;8(8):e020961.

Khan S, Khan A, Ali A, Naveed A , Rasool F, Khan H. Prevalence of Risk Factors for Coronary Artery Disease in Southern Punjab, Pakistan, Tropical J of Phar Res. 2016; 15 (1): 195-200.

James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, Evidence-based guideline for the management of high blood pressure in adults: report from the Eighth Joint National Committee (JNC-8). JAMA. 2014; 311(5):507-520.

Published
2018-12-01
How to Cite
Alamgir, M. A., Alamgir, I., Aqil, S., Qazi, M. A., Imran, A., Aslam, J., & Hassan, H. (2018). Identifying relationship of lipid profile with hypertension among diabetic patients. International Journal of Endorsing Health Science Research (IJEHSR), 6(4), 19-26. https://doi.org/10.29052/IJEHSR.v6.i4.2018.19-26